Redox imbalance dictates dependence on GOT1 versus GOT2 for rod photoreceptor health during aging and stress
in PRs demonstrates a neuroprotective effect after experimental RD suggesting decreased GOT2 expression may be part of a stress response to promote PR survival. Overall, this study illustrates the differential dependence on the GOTs for PR health, provides evidence that an overly reductive environment is detrimental to PR survival, and identifies GOT2 as a novel therapeutic target with potentially broad application in blinding diseases.
Authors
- Peter Sajjakulnukit (ORCID: https://orcid.org/0000-0002-8556-7481)
- Sraboni Chaudhury (ORCID: https://orcid.org/0000-0001-6785-2644)
- N. Edd Miller
- Thomas J. Wubben (ORCID: https://orcid.org/0000-0002-5183-3817)
- Katherine M. Weh (ORCID: https://orcid.org/0000-0002-7745-5391)
- Shubha Subramanya (ORCID: https://orcid.org/0009-0002-6976-575X)
- Eric Weh
- Navdeep S. Chandel (ORCID: https://orcid.org/0000-0001-7208-3886)
- Renee C. Ryals (ORCID: https://orcid.org/0000-0002-7182-7238)
- Meini Chen
- Costas Andreas Lyssiotis (ORCID: https://orcid.org/0000-0001-9309-6141)
- Moloy T. Goswami
- Heather Hager
- Emma Piraino
- Avi Weingarten
Institutions
- Northwestern University (US)
- Central South University (CN)
- Oregon Health & Science University (US)
- University of Michigan (US)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-04-07
- DOI
- https://doi.org/10.64898/2026.04.05.716322
- Primary Topic
- Retinal Development and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Eye Institute
- National Institute of Diabetes and Digestive and Kidney Diseases