Synthesis of Axially Chiral Styrenes via Pd-Catalyzed Atroposelective C–H Olefination
-disubstituted amide groups. A broad range of axially chiral styrenes were obtained in good to excellent yields and enantioselectivities (up to 80% yield and 95% ee) under mild conditions. Gram-scale reaction and further transformation reactions also provide a platform for synthetic applications of this method.
Authors
- Xu Wu (ORCID: https://orcid.org/0000-0002-6436-9611)
- Jiayi Bi
- Xue-Tao Xu (ORCID: https://orcid.org/0000-0002-6919-948X)
- Fei Yao (ORCID: https://orcid.org/0000-0002-8464-844X)
- Ya Gao (ORCID: https://orcid.org/0009-0001-0746-4129)
- Bing-Feng Shi
- Tao Zhou
Institutions
- Hangzhou Normal University (CN)
- State Key Laboratory of Pollution Control and Resource Reuse (CN)
- Henan Normal University (CN)
- Zhejiang University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-04-07
- DOI
- https://doi.org/10.1021/acs.orglett.6c00525
- Primary Topic
- Axial and Atropisomeric Chirality Synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Ministry of Education of the People's Republic of China
- National Key Research and Development Program of China