The COX2-PGE2-PKA Axis Suppresses Antiviral Immunity by Inhibiting mtDNA-Dependent STING Activation
/PKA axis as a negative regulator of mtDNA-STING signaling that may be targeted to potentiate STING-mediated type I IFN and innate immunity.
Authors
- Johannes Schöneberg (ORCID: https://orcid.org/0000-0001-7083-1828)
- Irène Wang (ORCID: https://orcid.org/0000-0002-3829-5217)
- Kuniaki Sato (ORCID: https://orcid.org/0000-0001-6014-1911)
- Pham Thuy Tien Vo (ORCID: https://orcid.org/0000-0001-5760-8461)
- Nevan J. Krogan (ORCID: https://orcid.org/0000-0003-4902-337X)
- Julien Cicero (ORCID: https://orcid.org/0000-0002-2069-6637)
- Hiroyuki Hakozaki (ORCID: https://orcid.org/0009-0008-2503-0480)
- Dana J. Ramms (ORCID: https://orcid.org/0000-0002-7700-1728)
- Uri Manor (ORCID: https://orcid.org/0000-0002-9802-1955)
- Erica Stevenson (ORCID: https://orcid.org/0000-0001-7853-1854)
- Danielle L. Swaney (ORCID: https://orcid.org/0000-0001-6119-6084)
- Sendi Rafael Adame-Garcia
- Yuan Zhou
- Thomas S Hoang
- Katie Fan
- J. Silvio Gutkind
Institutions
- Gladstone Institutes (US)
- University of California, San Francisco (US)
- University of California San Diego (US)
- Quantitative BioSciences (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-04-06
- DOI
- https://doi.org/10.64898/2026.04.03.716411
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health