Porphyromonas gingivalis drives trimethylamine-N-oxide accumulation via modulation of gut microbial trimethylamine lyase in mice

Introduction: modulates the choline-trimethylamine (TMA) axis remains unclear. Methods: ) were measured. Results: , consistent with the modulation of TMA/TMAO metabolism by these taxa. Conclusion: facilitates systemic TMAO elevation by reshaping gut microbial communities and enhancing choline-TMA lyase function, and compromising intestinal barrier integrity. These findings establish an oral-gut metabolic axis connecting periodontitis to host TMAO metabolism, and highlight promising periodontal and microbiota-targeted strategies for alleviating TMAO-associated systemic disorders.