From Hit to Lead: Systematic Optimization of the Quinazolinedione Scaffold as Potent and Noncytotoxic Antimalarial Agents
> 20 μM) indicating a high selectivity. This work validates the 7-halogenated quinazolinedione scaffold as a promising and selective chemotype for further antimalarial drug development.
Authors
- Duangporn Lohawittayanan (ORCID: https://orcid.org/0000-0002-3189-3185)
- Napason Chabang
- Rapatbhorn Patrapuvich (ORCID: https://orcid.org/0000-0001-8214-5710)
- Nattapon Pinthong (ORCID: https://orcid.org/0000-0002-0740-9496)
- Phongthon Kanjanasirirat (ORCID: https://orcid.org/0000-0002-1046-7152)
- Matthew Phanchana (ORCID: https://orcid.org/0000-0002-7736-7500)
- Kanthinich Thima
- Varisa Tantivess
- Patrick Schlaeppi
- Sitthivut Charoensutthivarakul (ORCID: https://orcid.org/0000-0002-4447-3438)
- Tachin Khulmanee
- Wanchalerm Yenjai
- Sanisorn Chotsriluecha
- Dhanita Chuchaisuwannasri
- Tanadej Phumisithikul
- Detchart Ratcha-in
Institutions
- Biocon (Switzerland) (CH)
- Mahidol University (TH)
- Drugs & Diagnostics for Tropical Diseases (US)
- Center for Neurosciences (US)
- Drug Discovery Laboratory (Norway) (NO)
- Hospital for Tropical Diseases (VN)
Publication Details
- Journal
- ACS Omega
- Published
- 2026-04-07
- DOI
- https://doi.org/10.1021/acsomega.5c12006
- Primary Topic
- Quinazolinone synthesis and applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Washington
- Thailand Center of Excellence for Life Sciences
- Mahidol University
- Ramathibodi Foundation
- Faculty of Tropical Medicine, Mahidol University
- Faculty of Science, Mahidol University