Vonoprazan–Amoxicillin Dual Therapy with or Without Saccharomyces boulardii Supplementation as a Rescue Regimen for Helicobacter pylori Infection

Background: ) infection has yet to be established. Methods: treatment failure were assigned to receive either vonoprazan (20 mg twice daily) plus amoxicillin (750 mg three times daily) (VA group) or the same regimen with S. boulardii (250 mg twice daily) (VAS group) for 14 days. Eradication rates, compliance, adverse events, and safety were assessed. Risk factors influencing the eradication rate were explored. Results: < 0.001). Both groups showed similar good compliance and safety. Conclusion: eradication rates and reduces adverse events, offering an effective and simple rescue treatment unaffected by previous treatment failures. Trial Registration: Chinese Clinical Trial Registry No. ChiCTR2300075382, September 4, 2023.