Hyperactive Rac converts sublethal to lethal trogocytosis in vivo
clones were required to cause germline killing. Increasing Draper expression or JNK activity in border cells also caused germline death, in a Rac-independent manner, suggesting that border cells can be activated to kill through multiple mechanisms. The series of events elucidated here reveals how hyperactivated Rac expressed in a few cells can trigger destruction of a much larger mass.
Authors
- Denise J. Montell (ORCID: https://orcid.org/0000-0001-8924-5925)
- Abhinava K. Mishra (ORCID: https://orcid.org/0000-0003-3733-3928)
- Lauren Penfield (ORCID: https://orcid.org/0000-0001-8380-3973)
- Morgan Smith
Institutions
- University of Louisville (US)
Publication Details
- Journal
- Proceedings of the National Academy of Sciences
- Published
- 2026-04-06
- DOI
- https://doi.org/10.1073/pnas.2534451123
- Citations
- 1
- Primary Topic
- Phagocytosis and Immune Regulation
- Type
- article
- Field-Weighted Citation Impact
- 13.13
Funders
- American Cancer Society
- National Institutes of Health