Ultrasound-Controlled Nano-Oxygen Delivery Modulates Endothelial Cells to Enhance Tumor Perfusion

subset. Clinical tumor samples corroborated these findings, showing elevated CapEC abundance and heightened ANGPT/VEGF pathway activity, specifically in high-proliferation CapECs. Functionally, ONB_FUS-mediated vascular repriming significantly enhanced intratumoral drug delivery and potentiated chemotherapy efficacy. Collectively, ONB_FUS offers a spatiotemporally controllable approach to vascular remodeling that complements standard-of-care therapeutics. Moreover, the identification of functionally distinct TEC subpopulations reveals mechanistically guided targets for precision antiangiogenic intervention.