Rewiring Metal-Dependent Cell Death to Unlock Immunotherapy in Colorectal Cancer
functions as a near-infrared II photothermal transducer and a source of copper and iron ions, inducing concurrent cuproptosis and ferroptosis via ion overload. Decitabine restores gasdermin E expression to couple oxidative stress with caspase-3-mediated pyroptosis, while chlorogenic acid repolarizes tumor-associated macrophages toward a pro-inflammatory phenotype. This coordinated multimodal cell-death cascade establishes a self-amplifying immunogenic circuit that suppresses tumor growth, sensitizes CRC to ICB, and elicits systemic antitumor immunity.
Authors
- Xue‐Jun Wu (ORCID: https://orcid.org/0000-0002-0470-8415)
- F. J. Cheng
- Jiaqi Wang (ORCID: https://orcid.org/0000-0003-1176-704X)
- Haixia Liu (ORCID: https://orcid.org/0000-0002-5443-2824)
- Ruyu Zhao
- Guan Zhang
- Lianhui Wang
- Xinyue Wang
Institutions
- Nanjing University of Posts and Telecommunications (CN)
- Smart Material (Germany) (DE)
- State Key Laboratory of Chemical Engineering (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Nano Letters
- Published
- 2026-04-06
- DOI
- https://doi.org/10.1021/acs.nanolett.6c00449
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Nanjing University of Posts and Telecommunications