Modular Defluorinative Annulation Enabled by a Dearomative Rearrangement: Diversified Synthesis of Azaheterocycles
-arylhydroxylamines and activated alkynes with or without amine. This protocol provides an efficient platform to prepare a diverse range of unusual three-dimensional functionalized oxa-aza[4.3.3]propellane- and indoline-related scaffolds in a modular pattern, which can greatly expend the chemical space of [3,3]-sigmatropic rearrangements.
Authors
- Zhonglin Wei (ORCID: https://orcid.org/0000-0002-9032-0889)
- Wei‐Wei Liao (ORCID: https://orcid.org/0000-0001-6225-4258)
- Li Huang (ORCID: https://orcid.org/0000-0002-5964-7090)
- Lei Yang
Institutions
- Jilin University (CN)
- Chinese Academy of Sciences (CN)
- Shanghai Institute of Organic Chemistry (CN)
- State Key Laboratory of Organometallic Chemistry
Publication Details
- Journal
- Organic Letters
- Published
- 2026-04-06
- DOI
- https://doi.org/10.1021/acs.orglett.6c01163
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Key Research and Development Program of China