Nickel-catalyzed ring-opening difunctionalization of methylenecyclobutanes via strain-release-enabled C-C activation

) frameworks in good to excellent yields under mild conditions. A broad substrate scope, scalability to the gram scale, and versatile downstream transformations demonstrate the synthetic utility of this approach. Mechanistic studies, including control, isotope-labeling experiments, and DFT calculations, reveal a distinct cooperative pathway involving strain-driven β-carbon elimination, offering new opportunities for catalyst-controlled activation of MCBs.