Wzi modulates immune evasion of hypervirulent <i>Klebsiella pneumoniae</i> in a CPS-dependent and independent manner
sequence polymorphisms significantly influenced serum resistance independent of CPS, with hvKP-associated alleles conferring the highest resistance. Our findings collectively highlight Wzi as a CPS-dependent and -independent virulence factor that mediates immune evasion and tissue invasion of hvKP, highlighting its potential as a therapeutic target for combatting hvKP infections.
Authors
- Jinquan Liu
- Sha Wei (ORCID: https://orcid.org/0009-0002-5417-6709)
- Jiexue Zhang
- Quanhang Xiang (ORCID: https://orcid.org/0000-0002-2437-0570)
- Tingting Xu (ORCID: https://orcid.org/0000-0002-9721-3971)
- Qingqing Du
- Dongliang Li
- Jialong Liu
- Lili Huang
- Yanru Chen
- Junlin Liu
Institutions
- Shenzhen University (CN)
- Southern University of Science and Technology (CN)
- Southern Medical University Shenzhen Hospital (CN)
- Shenzhen Second People's Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Virulence
- Published
- 2026-04-06
- DOI
- https://doi.org/10.1080/21505594.2026.2656049
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China
- Basic and Applied Basic Research Foundation of Guangdong Province