Tandem In Situ Nitro Reduction and Cyclization for the On-DNA Synthesis of Traditionally Privileged Skeletons
-nitroaniline derivatives, providing efficient one-pot access to benzimidazole scaffolds through tandem nitro reduction and cyclization with aldehydes. Compared to conventional stepwise sequences requiring isolated intermediates, this strategy provides a more streamlined and atom-economical route for constructing privileged pharmacophores directly on DNA.
Authors
- Xuanjing Shen (ORCID: https://orcid.org/0000-0002-9005-076X)
- Yueyue Xia
- Xinyuan Wu (ORCID: https://orcid.org/0009-0000-7565-6811)
- Caini He
- Zijian Liu
- Hongbin Xu
- Hanqing Zhao
- Xudong Wang
Institutions
- Nanjing University of Chinese Medicine (CN)
- Chinese Academy of Sciences (CN)
- Shanghai Institute of Materia Medica (CN)
- Ningbo University Affiliated Hospital (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Bioconjugate Chemistry
- Published
- 2026-04-06
- DOI
- https://doi.org/10.1021/acs.bioconjchem.6c00057
- Primary Topic
- Chemical Synthesis and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- State Key Laboratory of Drug Research