Proton-activated chloride channel 1 is essential for innate host defense against bacterial sepsis
sepsis survival but indifferent endotoxemia phenotypes. In conclusion, PACC1 links sterilizing phagolysosomal activity with immune networks in sepsis pathobiology.
Authors
- Markus Bosmann (ORCID: https://orcid.org/0000-0003-2773-1033)
- Seung Hoan Choi (ORCID: https://orcid.org/0000-0002-2797-3190)
- Matthew M. Helmkamp
- Marcel Strueve
- Sarah Walachowski
- Lucien P. Garo (ORCID: https://orcid.org/0000-0001-5369-1958)
- Kevin Brueck
- Archana Jayaraman
- Hulbert Yang
- C Reinhardt
Institutions
- Boston University (US)
- Johannes Gutenberg University Mainz (DE)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- German Center for Infection Research (DE)
- German Centre for Cardiovascular Research (DE)
Publication Details
- Journal
- Proceedings of the National Academy of Sciences
- Published
- 2026-04-06
- DOI
- https://doi.org/10.1073/pnas.2515768123
- Primary Topic
- Ion Transport and Channel Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- National Institutes of Health