The Transcription Factors <i>Six3</i> and <i>Six6</i> in Neuromedin‐S Neurons Differentially Affect Circadian Rhythms

allele turns on in the SCN after embryonic Day 16.5, limiting Cre-lox-mediated loss of Six3 or Six6 to the period after SCN neurogenesis. Using this approach, we hypothesized that Six3 and Six6 in NMS neurons regulate SCN circadian output and resulting reproductive function in males and females. Loss of Six6 from NMS neurons had no impact on puberty and reproduction. While loss of Six3 from NMS neurons had no effect in females, we found significantly decreased sperm motility in males, potentially through direct effects of Six3 in the testis. Loss of Six3, but not Six6, in NMS neurons resulted in shortened wheel-running periods in constant darkness, indicating a shortening of the endogenous rhythm within the SCN. Together, these data indicate a role of Six3 in determining the circadian period, suggesting differing functions of Six3 and Six6 in the adult SCN.

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Publication Details

Journal
Journal of Neuroscience Research
Published
2026-04-01
DOI
https://doi.org/10.1002/jnr.70123
Primary Topic
Circadian rhythm and melatonin
Type
article
Field-Weighted Citation Impact
0.00

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article

The Transcription Factors Six3 and Six6 in Neuromedin‐S Neurons Differentially Affect Circadian Rhythms

Lauren E. Chun, Duong Nguyen, Pamela L. Mellon, Jessica Cassin et al.
Journal of Neuroscience Research
Circadian rhythm and melatonin
article

The Transcription Factors Six3 and Six6 in Neuromedin‐S Neurons Differentially Affect Circadian Rhythms

Lauren E. Chun, Duong Nguyen, Pamela L. Mellon, Jessica Cassin, Meera M. Patel, Nay Chi P. Naing, Karen J. Tonsfeldt, Alexandra M. Yaw, Geneva A Dunn, Michael R. Gorman, Brooke M. Van Loh, Hanne M. Hoffmann
article en

Abstract

allele turns on in the SCN after embryonic Day 16.5, limiting Cre-lox-mediated loss of Six3 or Six6 to the period after SCN neurogenesis. Using this approach, we hypothesized that Six3 and Six6 in NMS neurons regulate SCN circadian output and resulting reproductive function in males and females. Loss of Six6 from NMS neurons had no impact on puberty and reproduction. While loss of Six3 from NMS neurons had no effect in females, we found significantly decreased sperm motility in males, potentially through direct effects of Six3 in the testis. Loss of Six3, but not Six6, in NMS neurons resulted in shortened wheel-running periods in constant darkness, indicating a shortening of the endogenous rhythm within the SCN. Together, these data indicate a role of Six3 in determining the circadian period, suggesting differing functions of Six3 and Six6 in the adult SCN.

Journal of Neuroscience ResearchVol. 104(4)
University of California San Diego (US), Reproductive Science Center (US), Michigan State University (US)
U.S. Department of Agriculture, Oregon Health and Science University, Michigan State University, National Institutes of Health, National Institute of Food and Agriculture, College of Engineering, Michigan State University, University of California, San Diego, National Institute of Neurological Disorders and Stroke, National Institute of Child Health and Human Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, School of Medicine, University of California, San Diego
Openalex Percentile: Top 39%
Circadian rhythm and melatonin
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