The Role of Nutritional and Inflammatory Indices in Predicting Prognosis in Older Adults Undergoing Radiotherapy for Lung Cancer: NIRT-LC Study

: In older adults with LC undergoing RT, pre-treatment immunonutritional indices were independently associated with overall survival. Lower inflammatory burden and higher nutritional scores were linked to improved outcomes. These indices were associated with mortality before RT across LC types, independent of disease stage. Among them, CALLY, PNI, and GNRI showed the strongest associations with mortality, suggesting that these markers may be promising candidates for pre-RT risk assessment. However, further validation in prospective cohorts is required before routine clinical implementation.