Exploring the Role of Hydrogen Bonding in Cyclodextrin─Naphthalenediimide Binding Orientation
C NMR titrations showed a selective downfield shift in two of the four carbonyls of NDIs that bind with β-CD, confirming the presence of hydrogen bonding. These results collectively demonstrate that targeted hydrogen bonding can control the position and orientation of the chromophore in β-CD complexes, thereby opening up avenues for rational design of noncovalent architectures.
Authors
- Saranya C. Sasi (ORCID: https://orcid.org/0000-0003-2739-695X)
- Rehin Sulay
- Retheesh Krishnan (ORCID: https://orcid.org/0000-0001-9564-1027)
- Sneha Anna Sunny
- Renjith Thomas
Publication Details
- Journal
- The Journal of Physical Chemistry B
- Published
- 2026-04-06
- DOI
- https://doi.org/10.1021/acs.jpcb.6c00517
- Primary Topic
- Drug Solubulity and Delivery Systems
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Royal Society of Chemistry