Microglia detection and phagocytosis of dying neurons is regulated by CX3CR1
deletion when both few and many neurons are dying leads to delayed cell corpse clearance, partly due to a delay in microglial engagement with the dying cells. Overall, our work uncovers a precise role for CX3CL1/CX3CR1 signaling in regulating the microglial response to dying neocortical neurons.
Authors
- Maryanne N. Barasa (ORCID: https://orcid.org/0000-0003-0208-0473)
- Alicia N. Pietramale
- Robert A. Hill
Institutions
- Dartmouth College (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-04-06
- DOI
- https://doi.org/10.64898/2026.04.02.716180
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute of Neurological Disorders and Stroke