Radical Smiles Rearrangements: Aryl Migration for Molecular Editing

extrusion versus retention, and recent advances in asymmetric sulfinyl-Smiles chemistry. We conclude by highlighting current limitations and future opportunities, especially in expanding substrate generality, stereocontrol, and late-stage functionalization, and in integrating Smiles rearrangements with electrochemical, flow, and data-driven catalysis for applications in medicinal chemistry and sustainable materials.