Systematic metabolic engineering of Escherichia coli for high-level production of pseudouridine via pathway optimization and precursor enhancement
pseudouridine. This work provides an efficient and scalable bioprocess for industrial pseudouridine manufacturing to meet the growing demands of mRNA-based applications.
Authors
- Yingjun Zhou (ORCID: https://orcid.org/0000-0003-4177-4742)
- Haiquan Yang
- Xianzhong Chen
- Yuanyuan Xia
- Li Zhou
- Wei Shen
- Jing Song
Institutions
- Jiangnan University (CN)
- Central South University (CN)
Publication Details
- Journal
- Synthetic and Systems Biotechnology
- Published
- 2026-04-06
- DOI
- https://doi.org/10.1016/j.synbio.2026.03.013
- Primary Topic
- Microbial metabolism and enzyme function
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Jiangnan University
- Higher Education Discipline Innovation Project
- National Key Research and Development Program of China