Ancient IL-6-STAT5 signaling orchestrates inflammation in jawless vertebrates
genes, consistent with an IL-6/STAT5/SOCS regulatory axis. These findings extend the repertoire of immune-related four-helix bundle cytokines to jawless vertebrates and indicate that IL-6-dependent inflammatory programs were already in place before the divergence of VLR-based and Ig/TCR-based adaptive immune systems in vertebrates.
Authors
- Jonathan P. Rast (ORCID: https://orcid.org/0000-0001-6494-0403)
- Francisco Fontenla-Iglesias (ORCID: https://orcid.org/0000-0002-5760-5102)
- J Lamas
- Thomas Boehm (ORCID: https://orcid.org/0000-0001-5172-7478)
- Jean‐Louis Boulay (ORCID: https://orcid.org/0000-0002-1401-7159)
- Sabyasachi Das (ORCID: https://orcid.org/0000-0002-9116-9623)
- Weiming Li
- Byron B Au-Yeung
- Masayuki Hirano
- Max D Cooper
Institutions
- Emory University (US)
- Universidade de Santiago de Compostela (ES)
- University Medical Center Freiburg (DE)
- University Hospital of Basel (CH)
- Department of Biomedicine Basel (CH)
- Max Planck Institute of Immunobiology and Epigenetics (DE)
- Max Planck Institute for Biology (DE)
- Michigan State University (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-04-06
- DOI
- https://doi.org/10.64898/2026.04.02.716188
- Primary Topic
- Aquaculture disease management and microbiota
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Emory University
- Georgia Research Alliance
- European Commission
- Max-Planck-Gesellschaft
- Ministerio de Ciencia e Innovación
- Xunta de Galicia
- National Institutes of Health
- School of Medicine, Emory University
- European Regional Development Fund