Ultrahigh-Throughput Enrichment of Circulating Tumor Cells from Whole Blood
cancer cells to blood cells. Remarkably, after only three rounds of sorting, cancer cells are enriched by 8 orders of magnitude with a recovery rate exceeding 90%. To showcase the utility of the platform as a clinical tool, we assay clinical blood samples from cancer patients, successfully isolating CTCs at an average concentration of 7.6 CTCs/mL. Such performance metrics confirm immediate utility in the enrichment of CTCs and as a minimally invasive biopsy tool in clinical diagnostics and cancer research.
Authors
- Mahmut Kamil Aslan (ORCID: https://orcid.org/0000-0003-3779-6797)
- Stavros Stavrakis (ORCID: https://orcid.org/0000-0002-0888-5953)
- Andrew J. deMello (ORCID: https://orcid.org/0000-0003-1943-1356)
- Alexander Ring (ORCID: https://orcid.org/0000-0002-0092-1323)
- Sarah Duclos Ivetich (ORCID: https://orcid.org/0009-0005-8201-221X)
- Q. N. Xu (ORCID: https://orcid.org/0000-0002-4884-9017)
- Tobias Weiss
- Yanan Zhang
Institutions
- Peking University (CN)
- University of Zurich (CH)
- Bioengineering (Switzerland) (CH)
- University Hospital of Zurich (CH)
- Center for Neurosciences (US)
Publication Details
- Journal
- ACS Sensors
- Published
- 2026-04-06
- DOI
- https://doi.org/10.1021/acssensors.5c04510
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Eidgenössische Technische Hochschule Zürich