Peptide Aptamer-Enabled Nanoplasmonic Digital Immunoassay for Ultrasensitive Cytokine Sensing in Early Inflammation and Immune Modulation
model of CAR T-cell-induced cytokine release, enabling high-frequency cytokine monitoring at early time points previously inaccessible to conventional assays. More broadly, this platform enables continuous, ultra-sensitive monitoring of cytokine dynamics at the onset of inflammation, opening new opportunities for early diagnosis and precision-guided intervention in a wide range of immune-mediated conditions.
Authors
- Yoolim Cha
- Jialiang Shen (ORCID: https://orcid.org/0000-0002-3572-7336)
- Xuejia Kang (ORCID: https://orcid.org/0000-0003-4336-2098)
- D. Kim
- Shuai Wu (ORCID: https://orcid.org/0000-0003-1677-0221)
- Kimberly Lackey
- Gangtong Huang (ORCID: https://orcid.org/0000-0001-8631-7014)
- Siyuan Dai
- Lang Zhou
- Pengyu Chen
- Feng Ding
- Chuanyu Wang
Institutions
- University of Alabama (US)
- Materials Design (France) (FR)
- University of Virginia (US)
- Clemson University (US)
- Auburn University (US)
Publication Details
- Journal
- ACS Sensors
- Published
- 2026-04-06
- DOI
- https://doi.org/10.1021/acssensors.5c04120
- Primary Topic
- Advanced Biosensing Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Alabama EPSCoR
- American Chemical Society Petroleum Research Fund
- National Institute of General Medical Sciences
- Division of Materials Research
- Division of Chemical, Bioengineering, Environmental, and Transport Systems