Aryl-Cyclohexanone as a potential CB2 agonist: <i>in vitro</i> and <i>in silico</i> evidence in inflammatory modulation
BACKGROUND: models. METHODS: docking and molecular dynamics analyses. RESULTS: experiments. CONCLUSION: The results demonstrate that AD exerts significant anti-inflammatory and immunomodulatory effects, associated with CB2 receptor agonism, highlighting its potential as a promising candidate for developing therapeutic strategies for handling inflammatory diseases.
Authors
- Leonardo Bruno Federico (ORCID: https://orcid.org/0000-0002-2943-8802)
- Tainá Larissa Lubschinski (ORCID: https://orcid.org/0000-0002-9938-2541)
- Luiz A.E. Pollo (ORCID: https://orcid.org/0000-0002-5870-1307)
- Eduardo Monguilhott Dalmarco
- Ziliani da Silva Buss
- Luigi Arruda Nardino
- Louis P. Sandjo (ORCID: https://orcid.org/0000-0001-5840-7733)
- Roberto Gomes de Carvalho Filho
- Maique Weber Biavatti
Institutions
- Universidade Federal de Santa Catarina (BR)
Publication Details
- Journal
- Immunopharmacology and Immunotoxicology
- Published
- 2026-04-06
- DOI
- https://doi.org/10.1080/08923973.2026.2655385
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico