Shared Genetic Architecture Between Kidney Function and Alzheimer Disease Across Ancestries
was the only shared locus across ancestries, underscoring ancestry-specific architectures with implications for risk prediction. The multi-scale approach used here also provides a methodological framework for dissecting complex disease relationships missed by traditional genome-wide analyses.
Authors
- Y. Yang
- Nicholas R. Ray
- Dana C. Crawford (ORCID: https://orcid.org/0000-0002-6437-6248)
- John R. Sedor (ORCID: https://orcid.org/0000-0002-6780-9168)
- Mengxuan Li (ORCID: https://orcid.org/0000-0001-8209-655X)
- Audrey Lynn
- Diya Yang
- Penelope Benchek
- Jonathan L. Haines
- John F. O'Toole
- Christiane Reitz
- Xiaofeng Zhu
- William S. Bush
Institutions
- Cleveland Clinic (US)
- Columbia University Irving Medical Center (US)
- Case Western Reserve University (US)
- Columbia University (US)
Publication Details
- Journal
- medRxiv
- Published
- 2026-04-06
- DOI
- https://doi.org/10.64898/2026.04.04.26350158
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00