A Novel Ultra‐Performance Liquid Chromatography‐Electrospray Ionisation‐Tandem Mass Spectrometry Method for Quantification of Imeglimin in Human Plasma: Application to a Bioequivalence Study

162.11 → 119.04. The proposed UPLC-tandem mass spectrometry method was thoroughly validated as per Food and Drug Administration principles over a linearity range of 10.0-3000.0 ng/mL and successfully applied for IMG quantification in human plasma samples. The scope of the work was extended to encompass real analysis of collected human blood samples, calculation of IMG pharmacokinetics parameters and conductance of a bioequivalence study between the IMG generic product versus brand one.

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Publication Details

Journal
Analytical Science Advances
Published
2026-04-06
DOI
https://doi.org/10.1002/ansa.70079
Primary Topic
Glycosylation and Glycoproteins Research
Type
article
Field-Weighted Citation Impact
0.00
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article

A Novel Ultra‐Performance Liquid Chromatography‐Electrospray Ionisation‐Tandem Mass Spectrometry Method for Quantification of Imeglimin in Human Plasma: Application to a Bioequivalence Study

Kamal A. Badr, Mamdouh R. Rezk, Mina Wadie, Ahmed A. Hosny et al.
Analytical Science Advances
Glycosylation and Glycoproteins Research
article

A Novel Ultra‐Performance Liquid Chromatography‐Electrospray Ionisation‐Tandem Mass Spectrometry Method for Quantification of Imeglimin in Human Plasma: Application to a Bioequivalence Study

Kamal A. Badr, Mamdouh R. Rezk, Mina Wadie, Ahmed A. Hosny, Liliya Logoyda, Omnia M. El Sebai
article en

Abstract

162.11 → 119.04. The proposed UPLC-tandem mass spectrometry method was thoroughly validated as per Food and Drug Administration principles over a linearity range of 10.0-3000.0 ng/mL and successfully applied for IMG quantification in human plasma samples. The scope of the work was extended to encompass real analysis of collected human blood samples, calculation of IMG pharmacokinetics parameters and conductance of a bioequivalence study between the IMG generic product versus brand one.

Analytical Science AdvancesVol. 7(1)
Cairo University (EG), Kyoto Pharmaceutical Industries (Japan) (JP), Agricultural Genetic Engineering Research Institute (EG), I.Horbachevsky Ternopil National Medical University (UA)
Openalex Percentile: Top 29%
Glycosylation and Glycoproteins Research
DOIOpen Access PDFOpenAlex
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A Novel Ultra‐Performance Liquid Chromatography‐Electrospray Ionisation‐Tandem Mass Spectrometry Method for Quantification of Imeglimin in Human Plasma: Application to a Bioequivalence Study — Kamal A. Badr, Mamdouh R. Rezk, et al. · Analytical Science Advances (2026) | TGRS Research Map | TGRS