A previously unappreciated class of metal-dependent bile salt hydrolases from the human gut microbiome
found in vertebrate gut microbiomes. Analysis of multi-omic datasets indicates metalloBSHs are expressed in vivo and correlate with BA metabolism. Overall, our findings reshape our understanding of BSH activity in the gut microbiome and highlight the promise of activity guided discovery in revealing previously overlooked gut microbial enzymes.
Authors
- Stephania M. Irwin (ORCID: https://orcid.org/0000-0001-9433-3807)
- Hannah E. Augustijn (ORCID: https://orcid.org/0000-0002-1862-6699)
- Heather Janine Kulik (ORCID: https://orcid.org/0000-0001-9342-0191)
- Emily P. Balskus (ORCID: https://orcid.org/0000-0001-5985-5714)
- Ruocheng Yu (ORCID: https://orcid.org/0000-0001-7268-7508)
- Miguel A. Aguilar Ramos (ORCID: https://orcid.org/0000-0002-2537-8371)
- Zheng Cui
- Anh T. P. Nguyen
- Panagiotis Papageorgiou Papageorgiou
- Christopher J. Meng
Institutions
- Howard Hughes Medical Institute (US)
- Harvard University (US)
- Massachusetts Institute of Technology (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-04-06
- DOI
- https://doi.org/10.64898/2026.04.05.716592
- Primary Topic
- Aldose Reductase and Taurine
- Type
- article
- Field-Weighted Citation Impact
- 0.00