Alkyltransferase Ribozyme for Site‐Specific <i>N</i> <sup>4</sup> ‐Cytidine Alkylation

-alkylated cytidine in a defined sequence context of a short RNA hairpin loop. In combination with tuning the electronic parameters of the transferred benzyl group, CSAR enables highly efficient cytidine alkylation for the installation of bioorthogonal functional groups.

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Publication Details

Journal
Angewandte Chemie International Edition
Published
2026-04-06
DOI
https://doi.org/10.1002/anie.6447137
Primary Topic
RNA modifications and cancer
Type
article
Field-Weighted Citation Impact
0.00
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article

Alkyltransferase Ribozyme for Site‐Specific N 4 ‐Cytidine Alkylation

Manisha B. Walunj, Claudia Höbartner, Evgeniia Dorinova
Angewandte Chemie International Edition
RNA modifications and cancer
article

Alkyltransferase Ribozyme for Site‐Specific N 4 ‐Cytidine Alkylation

Manisha B. Walunj, Claudia Höbartner, Evgeniia Dorinova
article en

Abstract

-alkylated cytidine in a defined sequence context of a short RNA hairpin loop. In combination with tuning the electronic parameters of the transferred benzyl group, CSAR enables highly efficient cytidine alkylation for the installation of bioorthogonal functional groups.

Angewandte Chemie International EditionVol. 65(20)
University of Würzburg (DE)
Openalex Percentile: Top 33%
RNA modifications and cancer
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