African swine fever virus pE199L, as a mitophagy receptor, suppresses antiviral innate immunity to promote viral replication

: 3-MA: 3-methyladenine; aa: amino acid; ASFV: African swine fever virus; CGAS: cyclic GMP-AMP synthase; co-IP: co-immunoprecipitation; CQ: chloroquine; DAPI: 4',6-diamidino-2-phenylindole; DNM1L/Drp1: dynamin 1 like; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GFP: green fluorescent protein; hpi: hour post-infection; IFN: interferon; LIR: LC3-interacting region; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MAVS: mitochondrial antiviral signaling protein; Mdivi-1: mitochondrial division inhibitor 1; MOI: multiplicity of infection; MT-CO2/COXII: mitochondrially encoded cytochrome c oxidase II; PINK1: PTEN induced kinase 1; poly(dA:dT): poly(deoxyadenylic-thymidylic) acid; poly(I:C): polyinosinic-polycytidylic acid; PRKN/PARK2: parkin RBR E3 ubiquitin protein ligase; siRNA: small interfering RNA; SQSTM1/p62: sequestosome 1; STING1: stimulator of interferon response cGAMP interactor 1; TBK1: TANK binding kinase 1; TOMM20: translocase of outer mitochondrial membrane 20; WT: wild-type.

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Publication Details

Journal
Autophagy
Published
2026-04-06
DOI
https://doi.org/10.1080/15548627.2026.2654982
Primary Topic
Animal Disease Management and Epidemiology
Type
article
Field-Weighted Citation Impact
0.00

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article

African swine fever virus pE199L, as a mitophagy receptor, suppresses antiviral innate immunity to promote viral replication

Yani Sun, Julian A. Hiscox, James P. Stewart, Yuchen Nan et al.
Autophagy
Animal Disease Management and Epidemiology
article

African swine fever virus pE199L, as a mitophagy receptor, suppresses antiviral innate immunity to promote viral replication

Yani Sun, Julian A. Hiscox, James P. Stewart, Yuchen Nan, Bin Ren, Z. Q. Zhu, Zhen Zhang, Xiaoyun Li, Jiakai Zhao, Miao Dan, Qin Zhao, Danyang Zhang
article en

Abstract

: 3-MA: 3-methyladenine; aa: amino acid; ASFV: African swine fever virus; CGAS: cyclic GMP-AMP synthase; co-IP: co-immunoprecipitation; CQ: chloroquine; DAPI: 4',6-diamidino-2-phenylindole; DNM1L/Drp1: dynamin 1 like; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GFP: green fluorescent protein; hpi: hour post-infection; IFN: interferon; LIR: LC3-interacting region; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MAVS: mitochondrial antiviral signaling protein; Mdivi-1: mitochondrial division inhibitor 1; MOI: multiplicity of infection; MT-CO2/COXII: mitochondrially encoded cytochrome c oxidase II; PINK1: PTEN induced kinase 1; poly(dA:dT): poly(deoxyadenylic-thymidylic) acid; poly(I:C): polyinosinic-polycytidylic acid; PRKN/PARK2: parkin RBR E3 ubiquitin protein ligase; siRNA: small interfering RNA; SQSTM1/p62: sequestosome 1; STING1: stimulator of interferon response cGAMP interactor 1; TBK1: TANK binding kinase 1; TOMM20: translocase of outer mitochondrial membrane 20; WT: wild-type.

Autophagy
University of Liverpool (GB), Lanzhou Veterinary Research Institute (CN), Northwest A&F University (CN)
National Natural Science Foundation of China
Good health and well-being
Openalex Percentile: Top 27%
Animal Disease Management and Epidemiology
DOISourceOpenAlex
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African swine fever virus pE199L, as a mitophagy receptor, suppresses antiviral innate immunity to promote viral replication — Yani Sun, Julian A. Hiscox, et al. · Autophagy (2026) | TGRS Research Map | TGRS