Ion Mobility Separation of Six Isomeric Cyclobutane Thymidine Photodimers Relevant to the Photochemistry of Non-B DNA Structures

-isomers. This work establishes a robust platform for gas-phase structural resolution of DNA photoproducts and may complement isotopic dilution-based strategies for quantification of these important photoproducts in vitro and in vivo. The combination of experimental and theoretical ion mobility provides new insights into the stereochemical diversity and structural dynamics of not only thymidine photo dimers but also dinucleotide photoproducts.