Mapping Slow Speckle Dynamics to Probe Cellular Metabolic Activity In Vivo using Laser Speckle Contrast Imaging

Significance: brain measurements is critical for translating speckle-based imaging beyond perfusion measurements to enable label-free assessment of cellular and metabolic activity in disease models. Aim: and evaluate its sensitivity to intracellular metabolic activity in brain tissue. Approach: measurements were performed to reveal SSD's response to hyperoxia and normoxia after ischemic stroke. Results: measurements, SSD increased during hyperoxia compared to normoxia after ischemic stroke, suggesting increased oxygen-supported cellular metabolic activity. Conclusions: measurements.