Chitosan-Based Thermosensitive Hydrogel Codelivering Berberine and Resveratrol Promotes Wound Healing of Bacterial Infection in Diabetic Mice

experiments using a diabetic mouse model with infected wounds showed that the CPP@BBR@RES hydrogel effectively inhibited bacterial colonization, alleviated the inflammatory response, and significantly promoted collagen deposition, angiogenesis, and wound closure. This study innovatively combines the thermogelling and sustained-release properties of the material with the synergistic antibacterial, anti-inflammatory, and repair-promoting functions of the dual drugs, providing a multifunctional integrated therapeutic strategy for diabetic infected wounds.