L‐Leucine Upregulates Lysosomal Biogenesis and Autophagy to Lower Plaques in <scp>5XFAD</scp> Mouse Model of Alzheimer's Disease
mice (5XFAD lacking PPARα), highlighting the involvement of PPARα in the neuroprotective effects of L-leucine. These results may be beneficial for AD patients.
Authors
- Susanta Mondal (ORCID: https://orcid.org/0009-0005-9505-0565)
- Ramesh Kumar Paidi (ORCID: https://orcid.org/0000-0003-3340-8056)
- Sukhamoy Gorai (ORCID: https://orcid.org/0000-0003-0115-3810)
- Kalipada Pahan (ORCID: https://orcid.org/0000-0001-6048-9598)
Institutions
- Rush University Medical Center (US)
- Jesse Brown VA Medical Center (US)
Publication Details
- Journal
- Journal of Neurochemistry
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1111/jnc.70432
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Veterans Affairs
- National Institutes of Health