Colonic metabolomic and transcriptomic alterations in a mouse model of metabolic syndrome
in MS NASH mice. Colonic organoids from MetS mice showed altered goblet cell differentiation. Comparative analysis with human MetS fecal metabolomics demonstrated similar dysregulated pathways, underscoring the translational relevance of these findings. Our study reveals significant metabolic and microbial alterations in the colon of MS NASH mice, implicating a dysfunctional GI tract as a potential etiological factor in MetS. These findings highlight specific metabolic pathways and microbial signatures that could serve as future therapeutic targets for MetS.
Authors
- Eliseo F. Castillo (ORCID: https://orcid.org/0000-0002-5083-560X)
- Audrey Nava
- Rama R. Gullapalli (ORCID: https://orcid.org/0000-0003-4441-1402)
- David Scieszka (ORCID: https://orcid.org/0000-0001-9357-7121)
- Seth D. Merkley (ORCID: https://orcid.org/0000-0002-4987-1195)
- Eduardo Peralta-Herrera
- Jaclyn A. Rivas
- Crystal Madera Enriquez
Institutions
- University of New Mexico (US)
- New Mexico Cancer Center (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-04-06
- DOI
- https://doi.org/10.64898/2026.04.02.716131
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Cancer Institute
- National Institute of General Medical Sciences
- National Center for Advancing Translational Sciences