DB-PTZ: A Novel NIR-II AIE Photosensitizer for Image-Guided Photothermal and Photodynamic Therapy of Hepatocellular Carcinoma
), DB-PTZ significantly increased intracellular ROS, induced apoptosis (44.74%), and inhibited the proliferation, migration, and invasion of HCC cells. In vivo, DB-PTZ selectively accumulated in tumors, providing potent growth suppression without measurable systemic toxicity. These results establish DB-PTZ as a hypoxia-tolerant NIR-II AIE photosensitizer with dual photothermal-photodynamic activity, offering a promising platform for precise, image-guided theranostics in HCC.
Authors
- Jun Tong (ORCID: https://orcid.org/0000-0001-8515-5375)
- Ce Zhang (ORCID: https://orcid.org/0000-0001-7350-4187)
- Shuanglin Han
- Changwei Dou (ORCID: https://orcid.org/0000-0003-1746-4859)
- Miaoyu Wei (ORCID: https://orcid.org/0000-0002-8125-551X)
- Lu Zhou
- Mu He
- Ting Zhou (ORCID: https://orcid.org/0000-0002-8475-5798)
- Zehao Yao
- Lidong Cao
- Yumeng Liu
- Muhammad Umar
- Weiyi Zhao
Institutions
- Zhejiang Chinese Medical University (CN)
- Hangzhou Normal University (CN)
- Dalian Medical University (CN)
- Second Affiliated Hospital of Dalian Medical University (CN)
- Zhejiang Provincial People's Hospital (CN)
- Hangzhou Medical College (CN)
Publication Details
- Journal
- ACS Applied Materials & Interfaces
- Published
- 2026-04-06
- DOI
- https://doi.org/10.1021/acsami.6c01570
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Department of Education of Liaoning Province
- Medical Science and Technology Project of Zhejiang Province
- Natural Science Foundation of Zhejiang Province