Genomic characterization of rabies virus glycoprotein co-expressing CD70 CAR-T cells during killing of glioma cells in vitro
Background: Chimeric antigen receptor T cell therapy has limited efficacy in the treatment of glioma due to the blood-brain barrier and T cell exhaustion. Enhancement with rabies virus glycoprotein (RVG29) has shown improved brain-related efficacy. Methods: . Results: ; glioma cells, furthermore, co-culture with glioma cells promoted the expansion of quiescent CD70R CAR-T cells. Conclusion: The RVG29 modification enhances CAR-T therapy for brain tumors and holds promise for treating glioma.
Authors
- Xianchen Wu
- Kexing Gao
- Feng Ji
- Hao Lin
Institutions
- Zhongda Hospital Southeast University (CN)
- Zhongshan Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-04-06
- DOI
- https://doi.org/10.3389/fimmu.2026.1680513
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China