Comparative single cell analysis of wound and cancer identifies the metabolic dialogues between tumor initiating stem cells and macrophages
tumorinitiating stem cells as key orchestrators that modulate the lipid metabolism of TAMs and shape their cell states. These findings suggest that disrupting the metabolic crosstalk between tumor-initiating stem cells and TAMs represents a promising strategy to normalize myeloid cell function and enhance cancer immunotherapy efficacy.
Authors
- Jianwen Que
- Benjamin Nicholson (ORCID: https://orcid.org/0000-0001-9958-7064)
- W. Guo
- Yuxuan Phoenix Miao
- Daniel Leon
Institutions
- University of Chicago (US)
- Columbia University (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-04-06
- DOI
- https://doi.org/10.64898/2026.04.02.716187
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- American Association for Cancer Research
- V Foundation for Cancer Research
- University of Chicago
- National Institutes of Health
- National Institute of General Medical Sciences