Dynamic Kinetic Resolution Enabled Synthesis of Planar and Central Chiral Ferrocenes
Ferrocene scaffolds with planar and central chirality are privileged motifs in enantioselective catalysis. Herein, we disclose a dynamic kinetic resolution (DKR) strategy in which chiral allenes enable consecutive axial-to-planar and axial-to-central chirality transfer, allowing the construction of planar and central chiral ferrocenes in up to 80% yield and 96% ee.
Authors
- Shilpi Bhardwaj
- Devendra Parganiha (ORCID: https://orcid.org/0000-0001-8826-7540)
- Sangit Kumar (ORCID: https://orcid.org/0000-0003-0658-8709)
- Ashwini Dilip Dhumale (ORCID: https://orcid.org/0009-0003-2434-9434)
- Vishal Choudhary
Institutions
- Indian Institute of Science Education and Research, Bhopal (IN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-04-06
- DOI
- https://doi.org/10.1021/acs.orglett.6c00779
- Primary Topic
- Axial and Atropisomeric Chirality Synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Department of Science and Technology, Ministry of Science and Technology, India
- University Grants Commission
- Science and Engineering Research Board