A rare glycoalkaloid biosynthetic pathway from wild potato unlocks genetic routes to Colorado potato beetle resistance
) retain apparently functional 23DOX and 23ACT orthologues, and that expression of 23DOX alone can restore leptine biosynthesis in certain cultivars. Collectively, these findings clarify the leptinine/leptine biosynthetic pathway, illustrate the co-option of a detoxification-related module into a defense system, and provide a genetic basis for breeding or engineering CPB-resistant potatoes.
Authors
- Hyoung Jae Lee (ORCID: https://orcid.org/0000-0002-4724-5908)
- Ryota Akiyama (ORCID: https://orcid.org/0000-0003-2116-4226)
- Naoyuki Umemoto (ORCID: https://orcid.org/0000-0001-5507-0848)
- Kazuki Saito (ORCID: https://orcid.org/0000-0001-6310-5342)
- Yukihiro Sugimoto (ORCID: https://orcid.org/0000-0002-8767-9671)
- Masaharu Mizutani (ORCID: https://orcid.org/0000-0002-4321-0644)
- Tetsuya Mori (ORCID: https://orcid.org/0000-0001-5347-8890)
- Kenji Asano
- Yuki Ikeyama
- Toshiya Muranaka
Institutions
- National Agriculture and Food Research Organization (JP)
- RIKEN Center for Sustainable Resource Science (JP)
- Agricultural Research Center (EG)
- Kobe University (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Proceedings of the National Academy of Sciences
- Published
- 2026-04-06
- DOI
- https://doi.org/10.1073/pnas.2537847123
- Primary Topic
- Potato Plant Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science