Dual-Receptor Targeted Imaging of Cancer Cells with a Bioorthogonal Iridium(III)-Based Probe
showed negligible luminescence in cell lines with low expression of CAIX, demonstrating its ability to discriminate cancer cells. Overall, this work demonstrates the promising potential of dual receptor-mediated iridium(III) complexes based on the bioorthogonal activation strategy for the accurate and specific imaging of cancer cells.
Authors
- Shaozhen Jing
- Jianmin Wu (ORCID: https://orcid.org/0000-0002-0999-9194)
- Wanhe Wang (ORCID: https://orcid.org/0000-0002-1458-6263)
- Daniel Shiu‐Hin Chan (ORCID: https://orcid.org/0009-0002-6204-3439)
- F Wang
- Jing Wang
- Kai Yang
- Chung-Hang Leung
- Chun-Yuen Wong
Institutions
- Shandong University of Technology (CN)
- City University of Hong Kong (HK)
- Northwestern Polytechnical University (CN)
- University of Macau (MO)
- State Administration of Traditional Chinese Medicine of the People's Republic of China (CN)
Publication Details
- Journal
- Inorganic Chemistry
- Published
- 2026-04-06
- DOI
- https://doi.org/10.1021/acs.inorgchem.6c00052
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Universidade de Macau
- Fundo para o Desenvolvimento das Ciências e da Tecnologia
- Science, Technology and Innovation Commission of Shenzhen Municipality
- State Key Laboratory of Quality Research in Chinese Medicine, University of Macau
- Key Research and Development Projects of Shaanxi Province
- Basic and Applied Basic Research Foundation of Guangdong Province