METTL14-dependent m <sup>6</sup> A modification restrains interferon signaling to prevent myocarditis and dilated Cardiomyopathy
A modification as a critical safeguard against cardiomyocyte-intrinsic IFN-I signaling and necroptosis and establish an epitranscriptomic-innate immune axis that drives inflammatory heart failure.
Authors
- Songxiao Zhong (ORCID: https://orcid.org/0000-0001-8426-3905)
- C. G. Tong
- Yong-Xiao Wang (ORCID: https://orcid.org/0000-0002-7483-3844)
- Jesse Zhu (ORCID: https://orcid.org/0000-0001-7749-8917)
- Patrick S DeSpain
- Reed A Rivera
- Tianru Zhang
- Changhao Li
- Jacob Kuempel
- Yu Xi
- A. Philip West
- Sukwon Choi
- Zhenyu Li
- Abi Osborn
Institutions
- University of Arizona (US)
- May Institute (US)
- Jackson Laboratory (US)
- Albany Medical Center Hospital (US)
- Texas A&M University (US)
- Bryan College (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-04-06
- DOI
- https://doi.org/10.64898/2026.04.02.716218
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00