Radiolabeling efficiency of FENTA chelators and stability of their terbium-161, lutetium-177 and bismuth-213 complexes
BACKGROUND: , as well as their kinetic inertness, was assessed and compared to the benchmark chelators DOTA and CHX-A"-DTPA. RESULTS: OAc, pH 6.0) and human serum after 90 min. CONCLUSION: FENTA exhibited favorable kinetic inertness with bismuth-213 over the 90 min timeframe, identifying it as a promising chelator. In contrast, further structural refinement is needed for its bifunctional analog.
Authors
- Wim Dehaen (ORCID: https://orcid.org/0000-0001-6979-5508)
- Thomas Cardinaels (ORCID: https://orcid.org/0000-0002-2695-1002)
- Tomas Opsomer (ORCID: https://orcid.org/0000-0002-8272-0292)
- Michiel Van de Voorde (ORCID: https://orcid.org/0000-0002-1176-9056)
- Sunay Rodríguez Pérez
- Cédric Bonneux
- Stephan Heinitz
- Maarten Ooms
- Veronique Bogaerts
Institutions
- Belgian Nuclear Research Centre (BE)
- KU Leuven (BE)
Publication Details
- Journal
- EJNMMI Radiopharmacy and Chemistry
- Published
- 2026-04-07
- DOI
- https://doi.org/10.1186/s41181-026-00438-y
- Primary Topic
- Radiopharmaceutical Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fonds Wetenschappelijk Onderzoek
- Herculesstichting