Feasibility of vancomycin AUC24 monitoring using peak and trough concentrations in pediatric patients: a prospective multicenter study

Background: monitoring using peak-trough concentrations in routine pediatric clinical practice and examine its correlation with the trough levels. Methods: was compared with the trough concentrations and dosing regimens. Results: range (400 μg h/mL-600 μg h/mL), whereas at troughs of 15 μg/mL-20 μg/mL, nearly half of the patients exceeded the safe exposure thresholds, underscoring the limitations of trough-based monitoring. Conclusion: estimation from peak and trough samples was feasible in routine pediatric workflow, providing more accurate exposure assessment than trough-guided monitoring. Implementation may improve efficacy and minimize nephrotoxicity.