Silver Nanoparticles Induce TET-Dependent Genome-Wide DNA Hydroxymethylation Alterations in Mouse Embryonic Stem Cells via Reactive Oxygen Species Signaling
ion. Our findings provide evidence that AgNPs disrupt TET-mediated DNA demethylation and reveal a novel epigenetic mechanism by which nanoparticles perturb DNA methylation homeostasis during early embryonic development.
Authors
- Weiyi Lai (ORCID: https://orcid.org/0000-0002-8010-2490)
- Shaokun Chen (ORCID: https://orcid.org/0000-0002-3289-9415)
- Junfa Yin (ORCID: https://orcid.org/0000-0001-8028-2375)
- Hailin Wang
Institutions
- Chinese Center For Disease Control and Prevention (CN)
- Chinese Academy of Sciences (CN)
- National Health and Family Planning Commission (CN)
- Institute for Advanced Study (DE)
- Taiwan Centers for Disease Control (TW)
- Research Center for Eco-Environmental Sciences (CN)
Publication Details
- Journal
- Chemical Research in Toxicology
- Published
- 2026-04-06
- DOI
- https://doi.org/10.1021/acs.chemrestox.6c00061
- Primary Topic
- Nanoparticles: synthesis and applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China