Total Synthesis of Isoriccardin C and Isoriccardin D Based on a Hydroxyl-Directed Palladium-Catalyzed Intramolecular C–H Alkenylation
-alkenylation that forges the 18-membered macrocyclic core. This streamlined route enables the total synthesis with minimal reliance on protecting groups, and its modular nature offers a versatile platform for the construction of structural analogues.
Authors
- P. Pasiero Losada
- José L. Mascareñas (ORCID: https://orcid.org/0000-0002-7789-700X)
- Moisés Gulías
Institutions
- Universidade de Santiago de Compostela (ES)
- Center for Research in Molecular Medicine and Chronic Diseases (ES)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-04-06
- DOI
- https://doi.org/10.1021/acs.orglett.6c00911
- Primary Topic
- Synthesis and Biological Activity
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Xunta de Galicia
- Instituto de Salud Carlos III
- European Regional Development Fund
- Agencia Estatal de Investigación