Spirocyclization-Enabled Remote Phosphorothiolation of Nonactivated Arenes via Dual Photoredox/Copper-Catalyzed Dearomatization
Spirocyclic frameworks are key structural motifs in bioactive molecules, driving ongoing efforts to develop efficient and sustainable synthetic methods. Herein, we report a synergistic photocatalysis/copper dual-catalytic system that enables direct dearomative spirocyclization via the simultaneous incorporation of phosphorothioate groups in a single synthetic operation. This strategy allows rapid, selective construction of complex spirocenters from simple nonactivated aromatic precursors, exhibits broad substrate scope, including bioactive relevant scaffolds, and provides a robust platform for diversity-oriented synthesis with significant potential in drug discovery.
Authors
- Yuzhen Gao (ORCID: https://orcid.org/0000-0002-2690-7407)
- Weiping Su
- Yu Du (ORCID: https://orcid.org/0000-0003-2287-5265)
- Jiale Zhang (ORCID: https://orcid.org/0009-0006-3650-7374)
- Siqing Liu
- Denghui Ma
Institutions
- Ningbo University of Technology (CN)
- Fujian Institute of Research on the Structure of Matter (CN)
- University of Chinese Academy of Sciences (CN)
- Fuzhou University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-04-06
- DOI
- https://doi.org/10.1021/acs.orglett.6c00996
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Haixi Institute, Chinese Academy of Sciences
- Natural Science Foundation of Fujian Province
- Ningbo University of Technology
- National Key Research and Development Program of China
- Fujian Science and Technology Innovation Laboratory for Optoelectronic Information of China