An empirical relationship between physicochemical properties and sublingual absorption of the model drugs

Drugs with lower lipophilicity and molecular flexibility exhibited faster sublingual absorption. These findings help to highlight the important physicochemical properties that may influence sublingual absorption.

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Publication Details

Journal
International Journal of Pharmaceutics
Published
2026-04-06
DOI
https://doi.org/10.1016/j.ijpharm.2026.126854
Primary Topic
Drug Solubulity and Delivery Systems
Type
article
Field-Weighted Citation Impact
0.00
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article

An empirical relationship between physicochemical properties and sublingual absorption of the model drugs

Rehab Abdelmonem, Sridivya Raparla, Pramila Sharma, Bhaskara Jasti et al.
International Journal of Pharmaceutics
Drug Solubulity and Delivery Systems
article

An empirical relationship between physicochemical properties and sublingual absorption of the model drugs

Rehab Abdelmonem, Sridivya Raparla, Pramila Sharma, Bhaskara Jasti, Xiaoling Li
article en

Abstract

Drugs with lower lipophilicity and molecular flexibility exhibited faster sublingual absorption. These findings help to highlight the important physicochemical properties that may influence sublingual absorption.

International Journal of PharmaceuticsVol. 696
University of the Pacific (US), Misr University for Science and Technology (EG)
Openalex Percentile: Top 26%
Drug Solubulity and Delivery Systems
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