Phenotypically and functionally unique CD86 expression CD8 T cell subset shapes immune regulation in the tumor microenvironment
INTRODUCTION: regulatory T cells have been described, their identity, upstream drivers and impact in tumors remain incompletely defined. OBJECTIVES: T cells in tumor immunity. METHODS: T cells mouse model. RESULTS: T cells reduced tumor growth, diminished CD39 and PD-1 on TILs, enhanced IFN-γ and granzyme B, and remodeled the myeloid compartment toward immunostimulatory DCs with elevated CD40/CD80/CD86 and reduced IDO/IL-10/CTLA-4/CD39. CONCLUSIONS: T cells may disrupt this suppressive circuit and potentiate antitumor immunity.
Authors
- Yifang Shui (ORCID: https://orcid.org/0009-0003-9114-4631)
- Weitao Que (ORCID: https://orcid.org/0000-0002-0544-3391)
- Miyuki Shindo (ORCID: https://orcid.org/0000-0002-3913-4992)
- Yixian Fan (ORCID: https://orcid.org/0000-0001-7950-0806)
- Shuji Takada (ORCID: https://orcid.org/0000-0002-9406-4683)
- Xiao‐Kang Li (ORCID: https://orcid.org/0000-0002-0897-2141)
- Xin Hu (ORCID: https://orcid.org/0000-0002-3253-6024)
- Miho Terao (ORCID: https://orcid.org/0000-0002-8391-083X)
- M Fujino
- Wen-Zhi Guo
Institutions
- National Center For Child Health and Development (JP)
- First Affiliated Hospital of Zhengzhou University (CN)
- Shenzhen Third People’s Hospital (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1016/j.jare.2026.04.006
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00