Psychosis Related to Nitrous Oxide Misuse: A Case Series and Systematic Review

O may be associated with psychotic episodes, particularly among young, heavy users with underlying vulnerabilities. Psychiatric and neurological symptoms are frequently observed. Although outcomes vary, treatment involving abstinence, vitamin B12 supplementation, and antipsychotic medication typically leads to improvement. Further research is warranted on this topic.

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Publication Details

Journal
Clinical Psychopharmacology and Neuroscience
Published
2026-04-06
DOI
https://doi.org/10.9758/cpn.25.1394
Primary Topic
Methemoglobinemia and Tumor Lysis Syndrome
Type
article
Field-Weighted Citation Impact
0.00
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article

Psychosis Related to Nitrous Oxide Misuse: A Case Series and Systematic Review

X. Acosta-Villalobos, Lara Grau-López, Josep Antoni Ramos-Quiroga, Laura Garriga-Solé et al.
Clinical Psychopharmacology and Neuroscience
Methemoglobinemia and Tumor Lysis Syndrome
article

Psychosis Related to Nitrous Oxide Misuse: A Case Series and Systematic Review

X. Acosta-Villalobos, Lara Grau-López, Josep Antoni Ramos-Quiroga, Laura Garriga-Solé, Raúl Felipe Palma-Álvarez, Germán Ortega-Hernández
article en

Abstract

O may be associated with psychotic episodes, particularly among young, heavy users with underlying vulnerabilities. Psychiatric and neurological symptoms are frequently observed. Although outcomes vary, treatment involving abstinence, vitamin B12 supplementation, and antipsychotic medication typically leads to improvement. Further research is warranted on this topic.

Clinical Psychopharmacology and NeuroscienceVol. 24(2)
Universitat Autònoma de Barcelona (ES), Centro de Investigación Biomédica en Red de Salud Mental (ES), Vall d'Hebron Institut de Recerca (ES), Centre for Biomedical Network Research on Rare Diseases (ES), Vall d'Hebron Hospital Universitari (ES)
Openalex Percentile: Top 25%
Methemoglobinemia and Tumor Lysis Syndrome
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