Clinical Use of Combined First‐Trimester Screening Test for Aneuploidy in A Low‐Income Setting: Retrospective Study

Background: Although combined first trimester screening is effective at detecting fetal chromosomal anomalies which are trisomy 21, 18 and 13, there is scarce data on its practice and practice in low-income countries. This study presents data on clinical use of combined first trimester prenatal screening tests among pregnant women in a Sub-Saharan setting. Methods: -value less than 0.05 was used to present significance of the results. Results: -value = 0.005). Conclusion: The prevalence of screening positive for high-risk aneuploidy in this study was higher than in previous reports which may be due to the fact that the study population is primary high-risk women. Nuchal translucency and low PAPP-A values were associated with screening positive for aneuploidy. Combined first trimester screening is feasible and effective for detecting fetal chromosomal anomalies in low-income settings. Laboratory capacity for performing serum analytes and genetic testing, and availability of nuchal translucency ultrasound services should acted up on for creating a wider access to such vital prenatal genetic screening and testing services.